Joshua Kennedy

as Robert Neville

Laura Laureano

as Lisa Cash

Kat Kennedy

as Matthias

Dexter John Scott

as Brother Zachary

Quinn Corcoran

as Family Member

Dan Day Jr.

as Narrator

Julian Flores

as Plague Victim

Troy Howarth

as Plague Victim

Xander Pretorius

as Family Member

Nick Ries

as Family Member

Traci Thomas

as Family Member

Jake Williams

as Family Member

Derek M. Koch

as Radio Announcer (voice) (uncredited)