Rainn Wilson

as Randy

Lil Rel Howery

as Mike

Aimee Carrero

as Jessica

Yvette Nicole Brown

as Shanice

Rob Riggle

as Dr. Serano

Page Kennedy

as Officer Taggert

Xolo Maridueña

as Rookie

Eric Jungmann

as Nurse Chad

Ayesha Harris

as Kim

Luka Jones

as Motorcycle Matt

Andy Milder

as Bruce

Dalia Rooni

as Rachel

Cameron Fuller

as Jimmy

Michael J. Sielaff

as Johnny

Joaquin Veizaga

as Vicente

Liam Oh

as Chip (uncredited)

Michael Monks

as Officer White

Patrick Pianezza

as Paramedic Patrick

Rafael Castillo

as Charlie (Mr. President)

Tree O'Toole

as Heroin Addict

Therese McLaughlin

as Crazy Woman

Peter Holden

as Angry White Guy

Melissa Bailey

as Charge Nurse

Treisa Gary

as Nurse Ruth

Sierra Swartz

as Jenna - Sorority Girl

Juan Pacheco

as Baseball Coach

Omar Leyva

as Vicente's Uncle

Aimee Li

as Nurse Colette

Andriana Garbiso

as ER Nurse

Adam Mondschein

as Drunk Rocky