Penélope Cruz

as Consuela Castillo

Ben Kingsley

as David Kepesh

Patricia Clarkson

as Carolyn

Peter Sarsgaard

as Kenneth Kepesh

Dennis Hopper

as George O'Hearn

Sonja Bennett

as Beth

Chelah Horsdal

as Susan Reese

Shaker Paleja

as Kris Banjee

Charlie Rose

as Charlie Rose

Kris Pope

as Consuela's Brother

Debbie Harry

as Amy O'Hearn

Antonio Cupo

as Younger Man

Michelle Harrison

as 2nd Student

Emily Holmes

as 1st Student

Marci T. House

as Administration Nurse

Tiffany Lyndall-Knight

as Actor #2 in Play

Tania Saulnier

as George's Girlfriend

Julian Richings

as Actor in Play #1

Alessandro Juliani

as Actor #3 in Play