Andy Samberg

as Ham III (voice)

Cheryl Hines

as Luna (voice)

Jeff Daniels

as Zartog (voice)

Patrick Warburton

as Titan (voice)

Kristin Chenoweth

as Kilowatt (voice)

Kenan Thompson

as Ringmaster (voice)

Zack Shada

as Comet / Nava Boy (voice)

Carlos Alazraqui

as Houston (voice)

Omid Abtahi

as Dr. Jagu (voice)

Patrick Breen

as Dr. Bob (voice)

Jane Lynch

as Dr. Poole (voice)

Kath Soucie

as Dr. Smothers (voice)

Stanley Tucci

as Senator (voice)

Wally Wingert

as Splork / Infinity Probe / Pappy Ham (voice)

Jessica Gee-George

as Ship Voice / Infinity Probe / Additional Voices (voice)

Tom Kenny

as Newsreel (voice)

Jason Harris

as Guard (voice)

Jess Harnell

as Additional Voices (voice)

Ellie Harvie

as Additional Voices (voice)

Caitlin McKenna

as Additional Voices (voice)