Robert De Niro

as Don Lino (voice)

Martin Scorsese

as Sykes (voice)

Will Smith

as Oscar (voice)

Renée Zellweger

as Angie (voice)

Jack Black

as Lenny (voice)

Ziggy Marley

as Ernie (voice)

Doug E. Doug

as Bernie (voice)

Shelley Morrison

as Mrs. Sanchez (voice)

David Soren

as Shrimp (voice)

David P. Smith

as Crazy Joe (voice)