Vijay

as Thalapathy Vetri Kondan 'Vetri'

Mamitha Baiju

as Vijayalakshmi 'Viji'

Bobby Deol

as John Himler / Amrish Poojari

Pooja Hegde

as Kayal

Priyamani

as Sheela Rani

Prakash Raj

as Roja Rangasamy

Gautham Vasudev Menon

as Srikanth

Narain

as Kaleel

Nassar

as CM Arivudai Nambi

Sunil Varma

as Velu

Monisha Blessy

as Viji's Friend

Teejay

as Karthik

Madan Gowri

as Vel

Muthukumar

as Ramesh Babu

Kobisan Chandrakumar

Vinod Sagar

as John Himler's Henchman

Revathi

as Vetri's Mother

Kumar Natarajan

as Armory Incharge

Baba Baskar

Ajay Rathnam

as DGP

Nelson Dilipkumar

as TV Reporter (Special Appearance)

Atlee

as TV Reporter(Special Appearance)

Lokesh Kanagaraj

as TV Reporter (Special Appearance)

Anirudh Ravichander

as Special Appearance (Song)

Nizhalgal Ravi

as Naranyanan

Raichal Rabecca Philip

as Porkodi

G. M. Sundar

as Loganathan

Srinath

as Ilyas

Ramachandran Durairaj

Sharath Ravi

Balaji Sakthivel

as Doctor

Gajaraj

as Karthik's Father

Kichcha Ravi

as porkodi's Husband

Sriman

as Yuvaraj

Vajrang Shetty

as John Himler's Henchman

Angelin

as Doctor

Ravi Raghavendra

A. L. Azhagappan

as Chief Minister

Mukhtar Khan

as Gilber Singh

Harshad