Marlon Wayans

as Shorty Meeks

Shawn Wayans

as Ray Wilkins

Anna Faris

as Cindy Campbell

Regina Hall

as Brenda Meeks

Damon Wayans Jr.

Gregg Wayans

as Brad Meeks

Kim Wayans

as Nurse Ratchett

Benny Zielke

Cameron Scott Roberts

as Jack Campbell

Cheri Oteri

as Gail Hailstorm

Chris Elliott

as Short Legs

Dave Sheridan

as Doofy Gilmore

Heidi Gardner

Lochlyn Munro

as Greg Phillippe

Olivia Rose Keegan

as Sara Campbell

Ruby Snowber

as Val

Savannah Lee Nassif

as Tuesday Campbell

Sydney Park

as Dei Meeks

Jon Abrahams

as Bobby Prinze

Nedim Jahić

as Rick Landers

Felissa Rose

Michael Leavy

Kai Cenat

Paige Mobley

Fedor Steer

as Scarifier

Chip Carriere

as Mall Santa

Hasani Vibez Comer

Anthony Anderson

as Mahalik

Kenan Thompson

as Jermaine Jackson