Frank Welker

as Fred Jones / Scooby-Doo (voice)

Casey Kasem

as Shaggy Rogers (voice)

Grey DeLisle

as Daphne Blake (voice)

Mindy Cohn

as Velma Dinkley (voice)

Kim Mai Guest

as Minga (voice)

René Auberjonois

as Alphonse LaFleur (voice)

Alfred Molina

as Professor Jeffries (voice)

James Sie

as Pemba Shepra (voice)

James Hong

as The High Lama (voice)

Jeff Bennett

as Dell Chillman / Pilot (voice)