Frank Welker

as Scooby-Doo / Fred Jones (voice)

Casey Kasem

as Shaggy Rogers (voice)

Mindy Cohn

as Velma Dinkley (voice)

Grey DeLisle

as Daphne Blake (voice)

Ron Perlman

as Captain Skunkbeard / Biff Wellington (voice)

Freddy Rodríguez

as Rupert Garcia (voice)

Tim Conway

as Skip Jones (voice)

Edie McClurg

as Peggy Jones / Sea Salt Sally (voice)

Kathy Najimy

as Sunny St. Cloud (voice)

Arsenio Hall

as Captain Crothers (voice)

Dan Castellaneta

as Mr. Mysterio / Woodenleg Wally (voice)