Paulette Goddard

as Lucretia Borgia

John Lund

as Alfonso D'Este

Macdonald Carey

as Cesare Borgia

Albert Dekker

as Vanetti

John Sutton

as Prince Bisceglie

Raymond Burr

as Michelotto

Donald Randolph

as Tiziano

Charles Dayton

as Bastino

Anthony Caruso

as Captain of the Guard

Dick Foote

as Negligent Sentry

William Farnum

as Conti Peruzzi

Kate Drain Lawson

as Gemma

Nicholas Joy

as Chamberlain

Fritz Leiber

as Filippo

Rose Hobart

as Lady Eleanora

Douglas Spencer

as False Physician

Nestor Paiva

as Mayor

Frank Puglia

as Bolfi

Houseley Stevenson

as Councillor

Robert Greig

as Councillor

Don Beddoe

as Councillor

Ian Wolfe

as Councillor (uncredited)