Queen Latifah

as M'Lynn

Alfre Woodard

as Ouiser

Phylicia Rashād

as Clairee

Jill Scott

as Truvy

Adepero Oduye

as Annelle

Dola Rashad

as Shelby

Tory Kittles

as Jackson

Afemo Omilami

as Drum

Lance Gross

as Sammy

Anna Colwell

as Nurse Pam

Jeff Rose

as Dr. Judd

Michael Beasley

as Spud

Demetrius Bridges

as Jonathan

Tom Key

as Owen Jenkins

Liana Loggins

as I.C.U. Patient

Karen Beyer

as Caterer

Mark Anthony Brooks

as Groom's Relative

Deonna Young

as Maid of Honor

Jejuan Smith

as Wedding (as Smith Jejuan)

James Busler

as Wedding / Reception Guest

Rultz Raymond

as Church Member

Simone Jameson

as Bridesmaid

Christian Higgins

as Wedding / Funeral Guest

Joselyn Jones

as Church Girl

Veronica Jackson

as Girl on second row

Richard A Moore

as Husband