Lacey Chabert

as Eliza Thornberry (voice)

Tom Kane

as Darwin (voice)

Cree Summer

as Phaedra (Elephant) (voice)

Tim Curry

as Nigel Thornberry / Col. Radcliff Thornberry (voice)

Lynn Redgrave

as Cordelia Thornberry (voice)

Danielle Harris

as Debbie Thornberry (voice)

Flea

as Donnie Thornberry (voice)

Crystal Scales

as Cheetah Cubs (voice)

Kimberly Brooks

as Tally (Cheetah Cub) (voice)

Alfre Woodard

as Akela (Cheetah Mother) (voice)

Brock Peters

as Jomo (voice)

Melissa Greenspan

as Sarah Wellington (voice)

Alexandra Boyd

as Victoria (voice)

Moira Quirk

as Jane (voice)

Jodi Carlisle

as Marianne Thornberry (voice)

Mae Whitman

as Schoolgirl (voice)

Marisa Tomei

as Bree Blackburn (voice)

Rupert Everett

as Sloan Blackburn (voice)

Earl Boen

as Gorilla (voice)

Kevin Michael Richardson

as Shaman Mnyambo (voice)

Brenda Blethyn

as Mrs. Fairgood (voice)

Tara Strong

as Schoolgirl (voice)

Hynden Walch

as Schoolgirl (voice)

Roger L. Jackson

as Reggie (Squirrel) / Thunder (voice)

John Kassir

as Squirrel (voice)

Charles Shaughnessy

as Squirrel (voice)

Jeff Coopwood

as Tim (Park Ranger) (voice)

Didier M. Ngole

as Ranger / BaAka Villager (voice)

Tony Okungbowa

as Ranger (voice)

Billy Brown

as Rhino (voice)

James Brown Orleans

as Zebu (voice)

Michael Chinyamurindi

as Cart Owner (voice)

Obba Babatundé

as Boko (voice)

Malonga Casquelourd

as BaKA Leader (voice)

Alu Amina

as BaKA Villager (voice)

Nsaka Kaninda

as BaAka Villager (voice)

B. Dido Tshimanga

as BaAka Villager (voice)

Camille Ntoto

as BaAka Villager (voice)

Colette Elimo

as BaAka Villager (voice)

Lunkeba Tezo

as BaAka Villager (voice)

Jeanne Klimi

as BaAka Villager (voice)

Inousca Kayombo

as BaAka Villager (voice)

Mata Mokwala

as BaAka Villager (voice)

Keith Szarabajka

as Poacher (voice)