Chiranjeevi

as Shankar Prasad / Shankar Dada

Srikanth

as ATM

Sonali Bendre

as Dr. Sunitha "Chitti"

Paresh Rawal

as Dr. J. Rama Lingeshwara Rao

Girish Karnad

as Satya Prasad

Vennira Aadai Nirmala

as Shankar Prasad's mother

M. S. Narayana

as Dr. Chidambaram MBBS, FRCS

Surya Bhagawan Das

as Dr. Mohammed Rafi

Deepti Nallamothu

as Meena

Sharwanand

as Vijay

Panja Vaisshnav Tej

as Cameo Appearance as Child Artist

Ali Basha

as Thief

Ahuti Prasad

as Corrupted Doctor

Gauahar Khan

as Special appearance in song

Venu Madhav

as Malhotra, Shankar's henchmen

Tirupati Prakash

Chalapathi Rao

Bhupinder Singh

as Pandu Dada

Banerjee

as Corrupted Faculty

Narsing Yadav

as Shankar's henchmen

Thotapalli Madhu

Athili Lakshmi

Duvvasi Mohan

Karate Kalyani Padala

Anjala Zaveri

as Cameo Appearance in “Chaila Chaila” song

Gauahar Khan

as Special appearance in the song "Naa Pera Kanchan Mala"

Pawan Kalyan

as Special appearance in song