Lluís Homar

as Rodrigo Borgia

Sergio Peris-Mencheta

as César Borgia

María Valverde

as Lucrecia Borgia

Paz Vega

as Caterina Sforza

Ángela Molina

as Vanozza

Katy Louise Saunders

as Giulia Farnese

Linda Batista

as Sancha de Aragón

Francesca Della Ragione

as Domiziana

Eusebio Poncela

as Cardenal Giuliano della Rovere

Eloy Azorín

as Jofré Borgia

Antonio Valero

as Cardenal Ascanio Sforza

David Lowe

as Ambassadeur Français

Lucía Jiménez

as María Enríquez

Esther Ortega

as Isabella

Benedetta Valanzano

as Pentesilea

Sergio Múñiz

as Juan Borgia

Roberto Enríquez

as Paolo Orsini

Antonio Dechent

as Michele Corella

Giorgio Marchesi

as Alfonso de Aragón

Marco Bocci

as Pedro Bembo

Fabio Grossi

as Cardenal Rafaele Riario

Antonio Hernández

as Cardenal Gianbatista Orsini

Massimo Vanni

as Soldier

Diego Martín

as Perotto

Enrique Villén

as Savanarola

Miguel Ángel Muñoz

as Ramón

Javier Tolosa

as Gonzalo de Córdoba

Federico Torre

as Macellaio

Roberto Álvarez

as Burkard

Unax Ugalde

Julio Mardelo

Xabier Murua

Eduardo Torroja