Fran Drescher

as Fran Fine (voice)

Charles Shaughnessy

as Maxwell Sheffield (voice)

Daniel Davis

as Niles (voice)

Lauren Lane

as C.C. Babcock (voice)

Nicholle Tom

as Maggie Sheffield (voice)

Benjamin Salisbury

as Brighton Sheffield (voice)

Madeline Zima

as Grace Sheffield (voice)

Pamela Adlon

as Chester the Dog (voice)

Maurice LaMarche

as The Rain Man (voice)