E. G. Daily

as Tommy Pickles (voice)

Christine Cavanaugh

as Chuckie Finster (voice)

Cheryl Chase

as Angelica Pickles (voice)

Susan Sarandon

as Coco LaBouche (voice)

John Lithgow

as Jean-Claude (voice)

Tara Strong

as Dil Pickles (voice)

Kath Soucie

as Lil Deville / Phil DeVille / Betty DeVille (voice)

Michael Bell

as Drew Pickles / Chaz Finster, Sr. (voice)

Cree Summer

as Susie Carmichael (voice)

Tress MacNeille

as Charlotte Pickles (voice)

Debbie Reynolds

as Lulu Pickles (voice)

Joe Alaskey

as Grandpa Lou Pickles (voice)

Mako

as Mr. Yamaguchi (voice)

Tim Curry

as Sumo Singer (voice)

Julia Kato

as Kira Watanabe-Finster (voice)

Billy West

as Sumo Singer (voice)

Dionne Quan

as Kimi Watanabe-Finster (voice)

Melanie Chartoff

as Didi Pickles (voice)

Casey Kasem

as Wedding DJ (voice)

Phil Proctor

as Howard DeVille (voice)

Lisa McClowry

as Princess (voice)

Dan Castellaneta

as Priest (voice)

Roger Rose

as Finster Wedding DJ (voice)

Kevin Michael Richardson

as Sumo Singer (voice)

Jack Riley

as Stu Pickles (voice)

Charlie Adler

as Inspector (voice)

Braden Wright

as Café Owner (voice)

Charles Fathy

as Photographer (voice)

Margaret Smith

as Stewardess (voice)

Phillipe Simon

as Animatronic Bus Driver (voice)

Paul Demeyer

as Dogcatcher / Street Cleaner (voice)

Richard Michel

as French Worker (voice)

Philip Benichou

as Ninja (voice)

Hannah Makragelidis

as Pre-School Kid (voice)

Shannon Stephens

as Pre-School Kid (voice)

Ben Sunderland

as Pre-School Kid (voice)