Kate Higgins

as Frankie Stein (voice)

Laura Bailey

as Lagoona Blue / Headless Headmistress Bloodgood (voice)

Salli Saffioti

as Clawdeen Wolf / Cleo de Nile (voice)

Debi Derryberry

as Draculaura (voice)

Evan Smith

as Deuce Gorgon / Gillington "Gil" Webber / Ted / Mike (voice)

Keith Silverstein

as Bartleby Farnum (voice)

Malcolm Danare

as Kipling (voice)

Erin Fitzgerald

as Abbey Bominable / Spectra Vondergeist / C.A. Cupid (voice)

Audu Paden

as Ghoulia Yelps / Manny Taur / Nightmare / Slo Mo (voice)

George Newbern

as Andy Beast (voice)

Jonathan Lipow

as The Tikis (voice)

Ogie Banks

as Clawd Wolf (voice)

Cam Clarke

as Heath Burns / Ghost (voice)

Cindy Robinson

as Jackson Jekyll / Holt Hyde / Operetta (voice)

America Young

as Howleen Wolf / Toralei / Elephant Girl 1 / Purrsephone (voice)