Ron Perlman

as Hellboy (voice)

Selma Blair

as Liz Sherman (voice)

Doug Jones

as Abe Sapien (voice)

Peri Gilpin

as Professor Kate Corrigan (voice)

Gwendoline Yeo

as Kitsune (voice)

Dee Bradley Baker

as Lightning / Kappa / Pilot (voice)

Phil LaMarr

as Bureau Member / Pilot / Additional Voices (voice)

Mitchell Whitfield

as Russell Thorne (voice)

Kim Mai Guest

as Additional Voices (voice)

Michael Hagiwara

as Additional Voices (voice)

Yuriana Kim

as Additional Voices (voice)

Clyde Kusatsu

as Additional Voices (voice)

Liza del Mundo

as Additional Voices (voice)

Paul Nakauchi

as Additional Voices (voice)

James Sie

as Additional Voices (voice)