Owen Wilson

as Reggie (voice)

Woody Harrelson

as Jake (voice)

Amy Poehler

as Jenny (voice)

George Takei

as S.T.E.V.E. (voice)

Colm Meaney

as Myles Standish (voice)

Keith David

as Chief Broadbeak (Voice)

Dan Fogler

as Governor William Bradford (voice)

Jimmy Hayward

as Ranger / Leatherbeak / President / Hazmats (voice)

Jeff Biancalana

as General Sagan / Hazmats (voice)

Danny Carey

as Danny (voice)

Carlos Ponce

as Narrator / Alejandro (voice)

Robert Beltran

as Chief Massasoit (voice)

Lesley Nicol

as Female Pilgrim (voice)

Kaitlyn Maher

as President's Daughter (voice)

Carlos Alazraqui

as Amos (voice)

Josh Lawson

as Gus (Voice)

Jason Finazzo

as Chrononaut One (voice)

Scott Mosier

as Pizza Dude (voice)

Lauren Bowles

as Jake's Mother (voice)

Dwight Howard

as Cold Turkey (Voice)

Vincente DiSanti

as (voice)

Jeffrey Fierson

as (voice)

David S. Lee

as (voice)

Rik Michul

as (voice)

Alina Phelan

as (voice)

William Morgan Sheppard

as (voice)

Frank Welker

as Dogs (voice) (uncredited)