Scott Wolf

as Scamp (voice)

Alyssa Milano

as Angel (voice)

Chazz Palminteri

as Buster (voice)

Jeff Bennett

as Tramp / Jock / Trusty / Dogcatcher (voice)

Jodi Benson

as Lady (voice)

Bill Fagerbakke

as Mooch (voice)

Mickey Rooney

as Sparky (voice)

Bronson Pinchot

as Francois (voice)

Cathy Moriarty

as Ruby (voice)

Mary Kay Bergman

as Si (voice)

Debi Derryberry

as Annette (voice)

Barbara Goodson

as Darling (voice)

Nick Jameson

as Jim Dear (voice)

Tress MacNeille

as Aunt Sarah / Am (voice)

Rob Paulsen

as Otis (voice)

Kath Soucie

as Collette / Danielle (voice)

Frank Welker

as Reggie (voice)

April Winchell

as Mrs. Mahoney (voice)

Jim Cummings

as Tony (voice)

Michael Gough

as Joe (voice)

Jess Harnell

as Buster (singing voice) (uncredited)

Andrew McDonough

as Junior (voice)

Susan Egan

as Angel (singing voice)