Ioan Gruffudd

as Reed Richards / Mr. Fantastic

Jessica Alba

as Sue Richards / Invisible Woman

Chris Evans

as Johnny Storm / Human Torch

Michael Chiklis

as Ben Grimm / The Thing

Julian McMahon

as Victor von Doom / Doctor Doom

Laurence Fishburne

as Norrin Radd / Silver Surfer (voice)

Doug Jones

as Norrin Radd / Silver Surfer

Kerry Washington

as Alicia Masters

Andre Braugher

as General Hager

Beau Garrett

as Frankie Raye

Brian Posehn

as Priest

Zach Grenier

as James Sherman / Rafke

Kenneth Welsh

as Dr. Jeff Wagner

Kevin McNulty

as Baxter Building Doorman

Andy Stahl

as Tailor

Debbie Timuss

as Hot Party Girl #1

Moneca Delain

as Hot Party Girl #2

Yan-Kay Crystal Lowe

as Hot Party Girl #3

Vanessa Lachey

as Johnny's Wedding Date

Stan Lee

as Stan Lee - Rejected Wedding Guest

Gonzalo Menendez

as Lieutenant

Giuliana Rancic

as Entertainment Reporter

Lauren Sánchez Bezos

as Fox News Reporter

Benjamin Ayres

as Guard #1

Patricia Harras

as Fan Four Receptionist

Fareed Abdelhak

as Egyptian Tour Guide

Dawn Chubai

as Anchorwoman

Alicia Thorgrimsson

as New York Pedestrian

Valerie Tian

as New York Teen Girl #1

Jeanna Haddow

as New York Teen Girl #2

Ali Costigan

as New York Teen Girl #3

Suzanne Ristic

as Airline Woman

Michasha Armstrong

as Wedding Security

Ulla Friis

as Danish News Anchor (uncredited)

Nimet Kanji

as Tourist in Egypt (uncredited)