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Nick Nolte
as Augusto Odone

Susan Sarandon
as Michaela Odone

Peter Ustinov
as Professor Nikolais

Ann Hearn
as Loretta Muscatine

Maduka Steady
as Omuori

Aaron Jackson
as Francesco Odone

Laura Linney
as Young Teacher

Kathleen Wilhoite
as Deirdre Murphy

Gerry Bamman
as Doctor Judalon

Margo Martindale
as Wendy Gimble

James Rebhorn
as Ellard Muscatine
Colin Ward
as Jake Gimble

LaTanya Richardson Jackson
as Nurse Ruth

Jennifer Dundas
as Nurse Nancy Jo
William Cameron
as Pellerman

Becky Ann Baker
as Pellerman's Secretary

Mary Pat Gleason
as The Librarian
David Shiner
as Clown

Ann Dowd
as Pediatrician

Peter MacKenzie
as Immunosuppression Doctor

Paul Lazar
as Professor Duncan
Joyce Reehling
as Columnist

Michael O'Neill
as School Psychologist

Richard Cordery
as Suddaby's Senior Manager

Angus Barnett
as Suddaby's Junior Manager

E. G. Daily
as Lorenzo Odone (voice)
Zack O'Malley Greenburg
as Lorenzo Odone

Sandy Gore
as Murphy Family

Nora Dunfee
as Murphy Family

Rocco Sisto
as Murphy Family

Amelia Campbell
as Murphy Family

Keith Reddin
as Murphy Family
Anthony DiLeo Jr.
as Conference Parent
Lianne Kressin
as Smiling Nurse
Nicolas Petrov
as World Bank Executive
Andrew M. Siegel
Assistant Property Master
Robin Alan Knight
Key Grip
Kathleen Gerlach
Assistant Costume Designer
Kimberly Walls
Assistant Editor

Daphne Paris
Associate Producer
Livia Ruzic
Dialogue Editor