Casey Kasem

as Shaggy Rogers (voice)

Frank Welker

as Fred Jones / Scooby-Doo (voice)

Mindy Cohn

as Velma Dinkley (voice)

Grey DeLisle

as Daphne Blake / Natasha (voice)

Christine Baranski

as Amelia von Butch (voice)

Ajay Naidu

as Prince Omar (voice)

Ron Perlman

as Hotep / Ancient One #2 (voice)

Jeremy Piven

as Rock Rivers (voice)

Wynton Marsalis

as Campbell (voice)

Oded Fehr

as Amahl Ali Akbar (voice)

Virginia Madsen

as Cleopatra (voice)