Christina Ricci

as Yellow (voice)

Sean Astin

as Horatio (voice)

Jessica Capshaw

as Duck (voice)

Craig Ferguson

as Nat (voice)

E. G. Daily

as (voices)

Rosie Perez

as Red (voice)

Tara Strong

as (voice)

Wayne Brady

as Blue (voice)

Owen Wilson

as Ricky The Dragon (voice)

Jess Harnell

as Green (voice)

David Kaye

as Black (voice)

Jeremy Guskin

as Professor Heliotrope (voice)

Frank Gladstone

as Astronaut (voice)

Zoë Bright

as Madame Pink (voice)

Sophia Eraklis

as Purple (voice)