Molly Shannon

as Mrs. Baker

Liam Aiken

as Owen Baker

Matthew Broderick

as Hubble (voice)

Donald Faison

as Wilson (voice)

Cheech Marin

as The Greater Dane's Henchman (voice)

Brittany Murphy

as Nelly (voice)

Vanessa Redgrave

as The Greater Dane (voice)

Carl Reiner

as Shep (voice)

Delta Burke

as Barbara Ann (voice)

Kevin Nealon

as Mr. Baker

Hunter Elliott

as Frankie

Mikhael Speidel

as Fred

Brittany Moldowan

as Connie Fleming

George Touliatos

as Mr. Leone

Patti Allan

as Ms. Ryan

Ben Immanuel

as Wilson's Dad (as Benjamin Ratner)

Peter Flemming

as Wilson's Other Dad

Paul Vogt

as Bob the Dog Catcher (as Paul C. Vogt)

Brenda Crichlow

as Mrs. Fleming (as Brenda M. Crichlow)

D. Harlan Cutshall

as Mr. Fleming

Chaka White

as Woman at the Pound

Nicola Anderson

as Woman at the Pound

Ted Friend

as TV Anchorman

Susan Bain

as House Bidder

Banner

as Barbara Ann

Willie

as Shep

Mig Macario

as Asian Dad (uncredited)