David Alan Basche

as Dale Sweeney

Patrick Warburton

as Dr. Seth Douglass

Patrick Gallo

as Officer Nick Senna

Cece Pleasants

as Paige Zinke

Chris MacKenzie

as Agent Bancini

Siobhan Fallon Hogan

as Larry Jean

Doc Dougherty

as Agent Cheswick

Fred Willard

as Mr. Fratus

Thomas Gibson

as Kyle Sweeney

Chris Elliott

as Eugene the Gator Guy

Ed Helms

as Leon

Mo Rocca

as Dr. Francis H. Flenderman, PHD

Susie Felber

as Rhonda from Melbourne Beach