Danny DeVito

as Cab Driver / Narrator (voice)

Lucy Liu

as Leo's Mother (voice)

Freddy Rodríguez

as Leo's Father (voice)

Brenda Song

as Big Sister (voice)

Fred Newman

as Little Spirit / Ramona / Squirrel / Pigeon (voice)

Rachel Schier

as Dylan (voice)

Brian Williams

as Rock Granite (voice)

Michael Hall D'Addario

as Leo (voice)

Sally Winters

as Girls' Mom / Knitting Lady (voice)

Todd Cummings

as Narrator - Dead Fish (voice)

Danny Tamberelli

as Snowball Fight Kid / Older Brother / Policeman (voice)

Veronica Taylor

as Younger Brother / Girl on Santa's Lap (voice)

Ramsey Faragallah

as Hot Dog Vendor (voice)

Les Mau

as Chinese Man (voice)

Sharon Wilkins

as African American Mom / African American Girl (voice)

Shawn Andrew

as Security Guard (voice) (as Shawn T. Andrew)