Laura San Giacomo

as Jenifer Estess

Jane Kaczmarek

as Valerie Estess

Annabella Sciorra

as Meredith Estess

Jane Alexander

as Marilyn Estess

Maddie Corman

as Julianne Hoffenberg

Edie Falco

as Wheelchair Saleswoman

Donna Hanover

as Herself

Camryn Manheim

as Nurse Vandemal

Julianna Margulies

as Jenifer's Psychiatrist

Rob Morrow

as Dr. Richard Feldman

Reed Rudy

as Scotty

Cedric Smith

as Dr. Richards

Vincent Spano

as Jack

Fisher Stevens

as Dr. Aaron Sanders

Marisa Tomei

as Nina Capelli

Bradley White

as Michael

Scott Wolf

as Jenifer's Date

Colin Ferguson

as Peter

Karen Robinson

as Lorna

Jason Blicker

as Neurologist

Robert Bockstael

as Researcher

Sarah Bolstridge

as Jenifer (Age 12)

Christopher Bondy

as Jenifer's Father (as Chris Bondy)

Johnie Chase

as Bus Driver

David Eisner

as Impatient Passenger

Alex Gaistman

as Jane (Age 3)

Imogen Haworth

as Valerie (Age 14)

Danny Mags

as Jake (age 6)

Mallory Margel

as Meredith (Age 11)

Jim McAleese

as Fire Marshal

Dean Mckenzie

as Waiter

Nadia-Leigh Nascimento

as Amy

Dave Nichols

as Doctor #2

Willis Robbins

as Willis

Jason Sharman

as (uncredited)