Frank Welker

as Curious George (voice)

Jeff Bennett

as The Man with the Yellow Hat / Mr. Rankins (voice)

Rino Romano

as The Narrator (voice)

Carlos Alazraqui

as Mr. Delgado / Luke / Gourds Gregory (voice)

Jim Cummings

as Jumpy Squirrel / Mr. Quint / Maurice (voice)

Lara Jill Miller

as Allie (voice)

Annie Mumolo

as Bill (voice)

Cree Summer

as Ada (voice)

Kath Soucie

as Mrs. Rankins / Mrs. Quint (voice)