Thomas Dekker

as Fievel Mousekewitz (voice)

Lacey Chabert

as Tanya Mousekewitz (voice)

Jane Singer

as Mama Mousekewitz (voice)

Nehemiah Persoff

as Papa Mousekewitz (voice)

Susan Boyd

as Nellie Brie (voice)

Robert Hays

as Reed Daley (voice)

Pat Musick

as Tony Toponi (voice)

Dom DeLuise

as Tiger (voice)

Candi Milo

as Madame Mousey (voice)

Jeff Bennett

as Slug (voice)

John Mariano

as Twitch (voice)

Joe Lala

as Bootlick (voice)

Sherman Howard

as Haggis (voice)

John Garry

as Lone Woof (voice)