Cara Buono

as Joanne

Isaach de Bankolé

as Abraham

David Lansbury

as Brian

Quinn Shephard

as Linda

Robert Peters

as Steve

Melissa Leo

as Miriam

Paul Lazar

as Larry

Helen Hanft

as Shirley

Jimmy Gary Jr.

as Sam

Rony Clanton

as Frank

Sharon Wilkins

as Jill

Joel de la Fuente

as Alien

Robert Downey Sr.

as Baker

Marcia Jean Kurtz

as Brian's Mom

Larry Block

as Brian's Dad

Lori Tan Chinn

as Mrs. Kim

Jay Oakerson

as Big Lab Assistant

Gregory Korostishevsky

as Small Lab Assistant

Kristen Schaal

as Information Librarian

Peter Bartlett

as Curator

Laura Esterman

as Psychiatrist

Susham Bedi

as Vegetarian

Ed Wheeler

as Guard

Jonah Meyerson

as Henry

Richard M. Davidson

as Doctor

David Smilow

as Science Reporter

Michael Clinton

as Farmer

Joseph McKenna

as Confessor

Lori Braverman

as Woman Gambler

Alberto Vasquez

as Jerry

Tyagi Schwartz

as Rosselli

Johann Carlo

as Frieda

Ethan Crough

as Jack

Kola Ogundiran

as Peter

Sean Sutherland

as Tourist

Peri Smilow

as News Reporter

Dwandra Nickole

as Admissions Person

Traci Parks

as Conservator