Haviland Stillwell

as Avia Trotter (voice)

Laura Bailey

as Headmistress Bloodgood / Lagoona Blue (voice)

Paula Rhodes

as Iris Clops / Sirena Von Boo (voice)

Kate Higgins

as Frankie Stein (voice)

America Young

as Howleen Wolf / Toralei Stipe (voice)

Erin Fitzgerald

as Abbey Bominable / Rochelle Goyle / Spectra Vondergeist (voice)

Geeg Friedman

as Bonita Femur (voice)

Salli Saffioti

as Clawdeen Wolf / Cleo de Nile (voice)

Evan Smith

as Deuce Gorgon / Gil Webber (voice)

Debi Derryberry

as Draculaura (voice)

Audu Paden

as Ghoulia Yelps / The Creature / Manny Taur (voice)

Jonquil Goode

as Gigi Grant / Twyla (voice)

Cam Clarke

as Heath Burns / Mr. Rotter / Hoodude Voodoo (voice)

Dave B. Mitchell

as Hexicah Steam (voice)

Cindy Robinson

as Jackson Jekyll / Operetta (voice)

Stephanie Sheh

as Jinafire Long (voice)

Luis Gonzalez

as Mr. Where (voice)

Josey Montana McCoy

as Neighthan Rot / Sparky / Victor Frankenstein (voice)

Julie Maddalena

as Robecca Steam / Venus McFlytrap (voice)