Thomas Dekker

as Fievel Mousekewitz (voice)

Lacey Chabert

as Tanya Mousekewitz (voice)

Nehemiah Persoff

as Papa Mousekewitz (voice)

Erica Yohn

as Mama Mousekewitz (voice)

Dom DeLuise

as Tiger (voice)

Elaine Bilstad

as Cholena (voice)

Pat Musick

as Tony Toponi (voice)

René Auberjonois

as Dithering (voice)

David Carradine

as Chief Wulisso (voice)

Sherman Howard

as Police Chief McBrusque (voice)

Tony Jay

as Toplofty (voice)

Richard Karron

as O'Bloat (voice)

John Kassir

as Scuttlebutt (voice)

Ron Perlman

as Grasping (voice)

Jean-Luc Galmiche

as Visqueux de Rat (voice)