Will Smith

as Dr. Bennet Omalu

Alec Baldwin

as Dr. Julian Bailes

Albert Brooks

as Dr. Cyril Wecht

Gugu Mbatha-Raw

as Prema Mutiso

David Morse

as Mike Webster

Arliss Howard

as Dr. Joseph Maroon

Mike O'Malley

as Daniel Sullivan

Eddie Marsan

as Dr. Steven DeKosky

Hill Harper

as Christopher Jones

Adewale Akinnuoye-Agbaje

as Dave Duerson

Stephen Moyer

as Dr. Ron Hamilton

Richard T. Jones

as Andre Waters

Paul Reiser

as Dr. Elliot Pellman

Luke Wilson

as Roger Goodell

Matthew Willig

as Justin Strzelczyk

Elizabeth Tulloch

as Keana Strzelczyk

Jason Davis

as Defense Attorney

Sara Lindsey

as Gracie

Kevin Jiggetts

as FBI Agent

Gary Grubbs

as FBI Agent

L. Scott Caldwell

as Waters' Mother

Joni Bovill

as Mrs. Scott

Joshua Elijah Reese

as Graveyard Tech

Holt McCallany

as Angry Neurologist

David Flick

as Hospital Security Guard

Kelley Davis

as Assistant

Samara Lee

as Strzelczyk's Daughter

Nathan Hollabaugh

as Young Reporter

Britanni Johnson

as Rachel Green

Randy Kovitz

as Deputy Mayor

Dan Ziskie

as Paul Tagliabue

Larry John Meyers

as Father D'Amico

Dan Anders

as College Coach

Jeb Keller

as High School Coach

Jackie Schafer

as TV Reporter (Webster Site)

Mike Clark

as TV Reporter (Interview)

Jared Pfennigwerth

as Tech

Phillip Chorba

as Tech

Alison Moir

as Colleen Bailes

Dino Rende

as Strzelczyk's Son

Cindy Jackson

as Paramedic

Scott Miller

as Contractor

Michael Schaich

as Security Guard

Hennessey Joseph

as NFL Employee

Antonia Long

as Piano Player

Lisa Earley

as Lodi Morgue Tech

Ann B. Betters

as Cantor

Joe Fishel

as Louisville Head Football Coach

Dihlon McManne

as Reporter at Westin

Brittney Aleah

as Altar Server (uncredited)

Christopher Boyer

as Crockett (uncredited)

Deborah Charity

as Attorney (uncredited)

Amy Lyn Elliott

as Business Woman (uncredited)

Joe Gallipoli

as Doctor (uncredited)

Carmen Gangale

as Doctor (uncredited)

Trevor Lee Georgeson

as NFL Mourner (uncredited)

David Gragg

as Football Coach (uncredited)

Eme Ikwuakor

as Amobi Okoye (uncredited)

Dontez James

as Corpse (uncredited)

Wendell Kinney

as NFL Football Player (uncredited)

David Dale McCue

as Pittsburgh Police Officer (uncredited)

Ben McDonnell

as Young Webster (uncredited)

Robert G. McKay

as Mr. Scott (uncredited)

F. Robert McMurray

as NFL Lawyer (uncredited)

Kimberly Ryans

as Business Woman (uncredited)

P. Scott Conner

as ER Doctor

Jared Scott

as Justin Strelczyk (uncredited)

Jackson Nunn

as Church Member (uncredited)