Frank Welker

as Fred / Scooby-Doo (voice)

Mindy Cohn

as Velma (voice)

Matthew Lillard

as Shaggy (voice)

Grey DeLisle

as Daphne (voice)

Gene Simmons

as Demon (voice)

Paul Stanley

as Starchild (voice)

Eric Singer

as Catman (voice)

Garry Marshall

as Manny Goldman (voice)

Doc McGhee

as Chip McGhoo (voice)

Pauley Perrette

as Delilah Domino (voice)

Rachel Ramras

as Shandi Strutter (voice)

Penny Marshall

as The Elder (voice)

Darius Rucker

as The Destroyer (voice)

Jennifer Carpenter

as Chikara (voice)

Jason Mewes

as Worker #1 (voice)

Kevin Smith

as Worker #2 (voice)

Tony Cervone

as Announcer (voice)

Tommy Thayer

as Spaceman (voice)