Alyssa Milano

as 26 (voice)

Jamie Kennedy

as Spazz (voice)

Kathy Griffin

as Rhoga (voice)

Wayne Knight

as Thudd (voice)

Malcolm McDowell

as Ogthar (voice)

Michael Clarke Duncan

as Stinktooth (voice)

George Segal

as Albagon (voice)

Diedrich Bader

as John (voice)

Tara Strong

as Mara (voice)

Gregg Berger

as SkyBax Patrolman (voice)

Alec Medlock

as Kex (voice)

Masasa Moyo

as Shanise (voice)