Zoe Saldaña

as Nina Simone

David Oyelowo

as Clifton Henderson

Mike Epps

as Richard Pryor

Ella Thomas

as Lorraine Hansberry

Ronald Guttman

as Henri Edwards

Ella Joyce

as Clifton's Mom

Keith David

as Clifton's Father

Mary Pat Gleason

as Ordlery Pat

Siena Goines

as Heather

Kit Leonard Dennis

as Lawyer

Yasmine Golchan

as Dr. Cousier

Ken Davitian

as Club Owner