Nikolaj Coster-Waldau

as Commander Frank Pike

Kerry Bishé

as Billie Kashmiri

Joy Bryant

as Alice Thibadeau

Jose Pablo Cantillo

as Manny Rodriguez

Ritchie Coster

as Dr. Jimmy Johnson

James D'Arcy

as Dr. Roger Fallon

Clea DuVall

as Sue Parsons

Gene Farber

as Val Orlovsky

Sienna Guillory

as Rika Goddard

Erik Jensen

as Dr. Jules Braun

Kari Wahlgren

as Jean (voice)

Nelson Lee

as Kenji Yamamoto

Omar Metwally

as Dr. Adin Meyer

Jimmi Simpson

as Virtual Man

Timothy Webber

as Union Sergeant

Ecstasia Sanders

as Kate Thibadeau

Catherine Thomas

as OB Nurse

Jennifer Mawhinney

as Pregnant Woman

Quinn Lord

as Shawn Braun

Graeme Duffy

as Roadie

Sheldon Yamkovy

as Lazerus

Dave Thompson

as Guitarist (uncredited)