Chris O'Dowd

as Dr. Cockroach (voice)

Riki Lindhome

as Susan Murphy/Ginormica (voice)

Eric Edelstein

as B.O.B. (voice)

James Patrick Stuart

as President Hathaway (voice)

Kevin Michael Richardson

as General Warren Monger (voice)

Gillian Jacobs

as Sta'abi (voice)

Jeff Bennett

as Coverton (voice)

Diedrich Bader

as The Missing Link (voice)