Casey Kasem

as Shaggy Rogers (voice)

Frank Welker

as Fred Jones / Scooby-Doo / The Centaur (voice)

Grey DeLisle

as Daphne Blake / Medusa (voice)

Mindy Cohn

as Velma Dinkley (voice)

Mark Hamill

as Barge Captain (voice)

Tara Strong

as Alexandra Viggi (voice)

James Arnold Taylor

as Sonny Les Matines / Guy L'Avorton (voice)

Nick Jameson

as Lysander Demas / Scary Looking Man (voice)

Phil LaMarr

as Toddy Stickfigger / Cabbie (voice)

Jess Harnell

as Lue / Shane Flinty / Constable (voice)

Daran Norris

as Ugo DiRinaldi / Shopkeeper (voice)

John DiMaggio

as Dragon / Officious Dwarf / Judge (voice)

Rob Paulsen

as Ripley / Pan Lute / Puny Guy (voice)

Jeff Bennett

as Feta Cheese Vendor / Major Portsmouth / Shop Owner (voice)

Moira Quirk

as Susie Smythe (voice)

Vanessa Marshall

as Danica LeBlake (voice)

Tasia Valenza

as Brooke Bjork (voice)