Ray Romano

as Manny (voice)

John Leguizamo

as Sid (voice)

Denis Leary

as Diego (voice)

Taraji P. Henson

as Ethel (voice)

Queen Latifah

as Ellie (voice)

Gabriel Iglesias

as Cholly Bear (voice)

Wendy Williams

as Condor Mom (voice)

Lili Estefan

as Gladys Glypto (voice)

Blake Anderson

as Clint (voice)

Keke Palmer

as Peaches (voice)

Seann William Scott

as Crash (voice)

Josh Peck

as Eddie (voice)

Seth Green

as Squint (voice)

Chris Wedge

as Scrat (voice)