Debi Derryberry

as Jimmy Neutron (voice)

Tara Strong

as Timmy Turner (voice)

Megan Cavanagh

as Judy Neutron (voice)

Mark DeCarlo

as Hugh Neutron (voice)

Rob Paulsen

as Carl Wheezer / Announcer (voice)

Jeffrey Garcia

as Sheen Estevez (voice)

Carolyn Lawrence

as Cindy Vortex (voice)

Crystal Scales

as Libby Folfax (voice)

Frank Welker

as Goddard (voice)

Susanne Blakeslee

as Wanda (voice)

Daran Norris

as Cosmo / Dad / Jorgen Von Strangle (voice)

Grey DeLisle

as Vicky / Principal Waxelplax (voice)

Carlos Alazraqui

as Denzel Crocker (voice)

Dee Bradley Baker

as Sanjay / Elmer / Fairy Agent #1 (voice)

Gary LeRoi Gray

as A.J. (voice)

Faith Abrahams

as Francis (voice)

Jim Ward

as Tour Guide (voice)

Jason Marsden

as Chester McBadbat (voice)