Debi Derryberry

as Jimmy Neutron (voice)

Tara Strong

as Timmy Turner (voice)

Jeff Garlin

as Villain (voice)

Rob Paulsen

as Carl / Eustace / Butler / Bucky McBadbat (voice)

Jeffrey Garcia

as Sheen Estevez (voice)

Carolyn Lawrence

as Cindy Vortex / Mrs. Folfax (voice)

Crystal Scales

as Libby Folfax (voice)

Mark DeCarlo

as Hugh Neutron (voice)

Megan Cavanagh

as Judy Neutron (voice)

Jason Marsden

as Chester McBadbat (voice)

Gary LeRoi Gray

as A.J. (voice)

Susanne Blakeslee

as Wanda / Mom (voice)

Daran Norris

as Cosmo / Dad (voice)

Carlos Alazraqui

as Mr. Crocker (voice)

Billy West

as Blix / British Official / Sam / Corky (voice)

Jay Leno

as Nega-Chin (voice)

Grey DeLisle

as Vicky (voice)