Kenneth Branagh

as Franklin Delano Roosevelt

Cynthia Nixon

as Eleanor Roosevelt

David Paymer

as Louis Howe

Tim Blake Nelson

as Tom Loyless

Matt O'Leary

as Fred Botts

Matt Malloy

as Lionel Purdy

Andy Davoli

as Jake Perini

Nelsan Ellis

as Roy Collier

Jane Alexander

as Sara Delano Roosevelt

Kathy Bates

as Helena Mahoney

Melissa Ponzio

as Lucy Mercer

Quint Von Canon

as Stephen Teller

Mike Pniewski

as Hastings

Grayce Spence

as League Member

Rand Hopkins

as Dr. Lovett

Brian F. Durkin

as Elliott Roosevelt

Carrie Adams

as Anna - Age 19

Georgia Miles

as Anna - Age 12

Devon Gearhart

as Elliot - Age 8 and 11

Tripp Hennington

as Franklin Junior - Age 9

Sam Frihart

as John - Age 7

Matthew Stanton

as Scoutmaster

Ron Clinton Smith

as Eugene

Lonnie R. Smith Jr.

as Stanley

Jill Jane Clements

as Waitress

Dave Hager

as Pat Doyle

Felicia Day

as Eloise Hutchinson

Meggie Geisland

as Daisy

E. Roger Mitchell

as Pete Collier

Deborah Duke

as Aunt Sally

Bob Seel

as Cleburne Gregory

Brian Beegle

as Benjamin Pendergrast

Steve Coulter

as Dr. Bissell

Marianne Fraulo

as Missy Lehand

Jody Thompson

as Woodhall Busey

Frank Hoyt Taylor

as Conductor

Lori Beth Sikes

as Mary Beth

Teal Sherer

as Chorus Girl #1

Margo G. Dietrich

as Chorus Girl #2

Laurel Lawson

as Chorus Girl #3

Danny Nelson

as Farmer

Sharon Blackwood

as Farmer's Wife

Bart Hansard

as Stationmaster at Bullochsville

Terry Loughlin

as Dr. Peter Hebert

Marc McPherson

as Dr. Willis

J.L. Parker

as Helena's Driver

Wilbur Fitzgerald

as Al Smith

Terrence Gibney

as Crony #1

David Silverman

as Crony #2

Robert C. Treveiler

as Dan Reed

Carl McIntyre

as Reporter

Greg Thompson

as Photographer

Ron Goss

as Convention Announcer