Paul Giamatti

as Barney Panofsky

Dustin Hoffman

as Izzy Panofsky

Rosamund Pike

as Miriam Grant-Panofsky

Minnie Driver

as The 2nd Mrs. P

Scott Speedman

as Boogie

Rachelle Lefevre

as Clara 'Chambers' Charnofsky

Bruce Greenwood

as Blair

Mark Addy

as Detective O'Hearne

Macha Grenon

as Solange

Jake Hoffman

as Michael Panofsky

Anna Hopkins

as Kate Panofsky

Saul Rubinek

as Charnofsky

Harvey Atkin

as 2nd Mrs. P's Father

Linda Sorensen

as 2nd Mrs. P's Mother

Brittany Drisdelle

as Girl at Cafe

Thomas Trabacchi

as Leo

Clé Bennett

as Cedric

Paul Gross

as Constable O'Malley of the North

Maury Chaykin

as Wedding Guest

Larry Day

as Bartender at Wedding

Mark Camacho

as T / U Productions Executive #1

Harry Standjofski

as Dr. Morty

Atom Egoyan

as O'Malley Director #1

David Cronenberg

as O'Malley Director #2

Ted Kotcheff

as Train Conductor

David Pryde

as T / U Productions Executive #1

Paula Jean Hixson

as Bartender at Grumpy's

Marica Pellegrinelli

as The Countess

Domenico Minutoli

as Judge at Rome Wedding

Massimo Wertmüller

as Rome Doctor

Howard Jerome

as Uncle Irv

Sam Stone

as Fundraising Target #1

Burney Lieberman

as Fundraising Target #2

Morty Bercovitch

as Fundraising Target #3

Pauline Little

as The 2nd Mrs. P's Housekeeper

Robin Kazdan

as Wedding Guest

Len Richman

as Rabbi

Sheila Hymans

as Rabbi's Wife

Kyle Switzer

as Production Assistant

Rebecca Croll

as Receptionist #1

Steve Bienstock

as NY Restaurant Waiter

Arthur Holden

as Notary

Zack Kifell

as Young Michael Panofsky

Simone Richler

as Young Kate Panofsky

Denys Arcand

as Maitre'D at Ritz

Arthur Grosser

as Mr. Dalhousie

Pascale Bourbeau

as Woman at Cemetery

Ellen David

as Massage Parlour Madame

Katia Di Perna

as Masseuse

Marina Eva

as Leo's Girlfriend

Sandra Lavoie

as Barney's One Night Stand

Ivana Shein

as Receptionist #2

Mélanie St-Pierre

as O'Malley's New Co-Star

Tarah Schwartz

as Reporter

Richard J. Lewis

as Pathologist

Howard Rosenstein

as Cousin Jeff