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Cast (61)
Kyrie Irving
as Uncle Drew
Lil Rel Howery
as Dax Winslow
Shaquille O'Neal
as Big Fella
Chris Webber
as Preacher
Reggie Miller
as Lights
Nate Robinson
as Boots
Lisa Leslie
as Betty Lou
Erica Ash
as Maya
Tiffany Haddish
as Jess
Nick Kroll
as Mookie Bass
Aaron Gordon
as Casper Jones
Mike Epps
as Louis
JB Smoove
as Angelo
W.W
Wesley Witherspoon
as Mario
T.M
Thomas Mills
as Duke Tango
Selema Masekela
as Sal Masekela
Adam Lazarre-White
as Frankie the Tournament Director / Narrator
L.W
Lavar Walker
as Marty the Manager
John Calipari
as John Calipari
J.H
Joe Hammond
as Joe Hammond
S.J
Scoop Jackson
as Scoop Jackson
P.K
Pee Wee Kirkland
as Pee Wee Kirkland
Earl Monroe
as Earl Monroe
Chris Mullin
as Chris Mullin
M.S
Maurice G. Smith
as Dominic 'The Glove' Willis
Kevin Benton
as Zeke 'The Mouth' Murray
Bill Walton
as Bill Walton
George Gervin
as George Gervin
Steve Nash
as Steve Nash
David Robinson
as David Robinson
Jerry West
as Jerry West
Rick Barry
as Rick Barry
Dikembe Mutombo
as Dikembe Mutombo
NeNe Leakes
as Nene Leakes
A.W
Aiden Williams
as Adopted Kid
T.A
Tinuke Adetunji
as Angelo's Girl
Deadra Moore
as Desk Nurse
Enoch King
as Baby's Dad
Crystal Lee Brown
as Mom
K.C
Kenneth Crudup
as Baller
M.E
Mark Robert Ellis
as Basketball Coach (as Mark Ellis)
Terence Rosemore
as Customer #1
Terrence 'T.C.' Carson
as Customer #2
Rick Ross
as Customer #3
T.G
Trey Griffith
as Dax - 4 Years Old
J.H
Judah Howery
as Dax - 10 Years Old
Ashton Tyler
as Young Dax
Carrie Walrond Hood
as Foot Locker Mother
L.D
Lorenzo Davis
as Opponent
B.K
Brian Kortovich
as Opponent
Keith Jamal Evans
as Other Kid (as Keith Evans)
Josh Henry
as Paramedic
P.D
Phil Ductan
as Player
Elijah Everett
as Player
R.P
Rocco Poveromo
as Referee
B.R
Barry Rohrssen
as Referee
Scott Van Pelt
as Scott Van Pelt - ESPN Host (uncredited)
Jamel Chambers
as Angry Fan
Alannah Wilhite
as Girl in club
M.M
Matt McHugh
as Security Guard
Dario A. Lee
as The Destroyer (uncredited)
