T-Pain

as Freaknik (voice)

Joey Galaxy

as Virgil (voice)

Cee Lo Green

as Lite Skinn'd (voice)

Rick Ross

as Big Uzi (voice)

DJ Pooh

as Doela Man (voice)

Lil Jon

as Foreboding Old Dude (voice)

Big Boi

as Preacher (voice)

DJ Drama

as Mr. Thanksgiving (voice)

Snoop Dogg

as Gang Member (voice)

Kelis

as (voice)

Mack Maine

as (voice)

Sophia Fresh

as Leacosia / Toprameneesha / Obamaniqua / Suzie (voice)

Lil Wayne

as Trap Jesus (voice)

Charlie Murphy

as (voice)

Bill Hader

as Tad (voice)

Andy Samberg

as Chad (voice)

George Clinton

as (voice)

Bootsy Collins

as (voice)

Kel Mitchell

as Fruit Bowl Boys Leader (voice)

Liz Benoit

as Oprah Winfrey (voice)

Gene Anderson

as (voice)

Reginald Boyland

as (voice)

Christopher Reid

as (voice)

Christopher Martin

as (voice)

Affion Crockett

as (voice)

Corey Burton

as (voice)

Carl Jones

as Virgil's Boss (voice)

Heather Lawless

as (voice)