Steven Weber

as Charlie B. Barkin (voice)

Dom DeLuise

as Itchy Itchiford (voice)

Bebe Neuwirth

as Anabelle / Belladonna (voice)

Sheena Easton

as Sasha La Fleur (voice)

Ernest Borgnine

as Carface Carruthers (voice)

Charles Nelson Reilly

as Killer (voice)

Beth Andersen

as Martha (voice)

Taylor Emerson

as Timmy (voice)

Myles Jeffrey

as Scruffy (voice)

Aria Noelle Curzon

as Female Puppy Angel (voice)

Ashley French

as Female Puppy (voice)

Laurie A. Schillinger

as Additional Voices (voice)