Neil Patrick Harris

as Dr. Philip O'Hanlon (voice)

Bea Miller

as Virginia O'Hanlon (voice)

Jennifer Love Hewitt

as Mrs. Laura O'Hanlon (voice)

Alfred Molina

as Francis Church (voice)

Robb Pruitt

as Santa (voice)

Andrew Cherry

as George (voice)

Taylor Hay

as Taylor (voice)

Michael Buscemi

as Scraggly Santa (voice)