Christine Cavanaugh

as Charles 'Chuckie' Finster Jr. (voice)

Cheryl Chase

as Angelica C. Pickles (voice)

Kath Soucie

as Phillip 'Phil' DeVille/Lillian 'Lil' DeVille/Elizabeth 'Betty' DeVille (voice)

Tara Strong

as Dylan Prescott 'Dil' Pickles (voice)

Cree Summer

as Susan 'Susie' Carmichael (voice)

Tress MacNeille

as Charlotte C. Pickles (voice)

Melanie Chartoff

as Didi Pickles (voice)

Jack Riley

as Stu Pickles (voice)

Joe Alaskey

as Louis 'Grandpa' Pickles (voice)

Michael Bell

as Drew Pickles/Charles 'Chaz' Finster, Sr. (voice)

Charlie Adler

as Professor Spooky (voice)

E. G. Daily

as Tommy Pickles (voice)